Abstract

Studies of major depressive disorder have been correlated with reduced Lactobacillus and Bifidobacteria and symptom severity has been correlated to changes in Firmicutes, Actinobacteria, and Bacteriodes. Gut microbiota that contain more butyrate producers have been correlated with improved quality of life (1).


A study in healthy women providing probiotic yogurt for four weeks showed an improvement in emotional responses as measured by brain scans (2). A subsequent study by Mohammadi et al. (3) investigated the impacts of probiotic yogurt and probiotic capsules over 6 weeks and found a significant improvement in depression-anxiety-stress scores in subjects taking the specific strains of probiotics contained in the yogurt or capsules. Other studies with probiotics have indicated improvements in depression scores, anxiety, postpartum depression and mood rating in an elderly population (4-7).


Other studies have indicated a benefit of probiotic supplementation in alleviating symptoms of stress. In particular, researchers have looked at stress in students as they prepared for exams, while also evaluating other health indicators such as flu and cold symptoms (1). In healthy people, there is an indication that probiotic supplementation may help to maintain memory function under conditions of acute stress.

Skin Aging and Peptides

Skin aging is influenced by both intrinsic and extrinsic factors, including genetics, ultraviolet radiation exposure, pollution, and oxidative stress. As skin ages, there is a noticeable decrease in the production of collagen and elastin—proteins that provide structure, firmness, and elasticity. Additionally, cellular regeneration slows, and the skin’s ability to retain moisture diminishes, resulting in thinner, drier skin with wrinkles and fine lines.


In the dynamic and evolving field of cosmetic research, peptides have been identified as crucial components with a vast range of applications, especially in antiaging products. Peptides, short chains of amino acids, can penetrate the skin more easily due to their smaller size. Their essential role in various biological functions, cell communication, and activation of specific biological processes makes them highly effective for enhancing skin appearance.

CLAIMS

The quest for antiaging solutions has led to an array of claims regarding the efficacy of various treatments and products. This underscores the need for rigorous trials and evaluation methods to validate these claims.

Clinical trials are paramount in this context, as they provide a systematic approach to assess the safety and efficacy of antiaging interventions. Randomized controlled trials (RCTs), double-blind studies, and longitudinal assessments are among the gold standards in research, ensuring that outcomes are reliable and not influenced by bias.


Evaluating these claims through well-designed studies helps to distinguish scientifically validated treatments from those that are merely marketing hype, ultimately guiding consumers and professionals toward effective antiaging strategies.


3D image of skin deformation under positive pressure

Macroscopic Changes
The approach to evaluate antiaging efficacy in vivo on subjects is very broad, but measurements of firmness and volumes are among the most important ones. As aging occurs, significant changes in the skin and underlying structures take place. A key factor is the decrease in collagen and elastin production, leading to wrinkles, fine lines, and sagging.


Additionally, the subcutaneous fat that provides support and contour to the skin diminishes and redistributes with age. This loss of volume results in a hollow or sunken appearance in areas such as the cheeks and temples, contributing to the formation of deep folds, such as nasolabial folds and marionette lines. Aging also affects facial bones and muscles, causing a loss of density and mass, exacerbating the loss of structure and support, and leading to increased sagging and skin laxity. The combination of these factors results in less defined contours and an overall aged appearance.


There are various cosmetic treatments, medical devices, and procedures that can address these effects. One of the options to evaluate the efficacy of these treatments would be through two complementary devices.


The first one is a high-resolution 3D scanning sensor that captures facial images and skin relief. This technology quantifies changes in wrinkles, folds, and volumes in different areas such as the glabella, nasolabial folds, marionette lines, and the facial oval.


The second one is a non-contact device for measuring skin firmness. It produces bilateral blowing that creates controlled deformation on the cheek, which is then captured at different times by the EvaFACE. Measurements are taken before, during, and after the air blows, generating baseline images, deformation states, and relaxation states. This system primarily measures firmness by calculating the volume of the depression produced by the air.


To obtain reliable results, a well-structured trial design is crucial, focusing on the appropriate panel, the mode of action of the formulation or routine being tested, and including a sufficient number of participants to obtain statistically significant data.


In summary, antiaging efficacy can be assessed through the integration of scientific innovation and advanced technology. A rigorous focus on research and development is essential for optimizing results. This approach supports the creation of cosmetic products that not only delay the signs of aging but also promote overall skin health and appearance. The combination of scientific and technological knowledge ensures the development of effective and high-quality products, backed by thorough research and testing.


Biotic ingredients with a proven skin anti-ageing effect

Studies of major depressive disorder have been correlated with reduced Lactobacillus and Bifidobacteria and symptom severity has been correlated to changes in Firmicutes, Actinobacteria, and Bacteriodes. Gut microbiota that contain more butyrate producers have been correlated with improved quality of life (1).


A study in healthy women providing probiotic yogurt for four weeks showed an improvement in emotional responses as measured by brain scans (2). A subsequent study by Mohammadi et al. (3) investigated the impacts of probiotic yogurt and probiotic capsules over 6 weeks and found a significant improvement in depression-anxiety-stress scores in subjects taking the specific strains of probiotics contained in the yogurt or capsules. Other studies with probiotics have indicated improvements in depression scores, anxiety, postpartum depression and mood rating in an elderly population (4-7).


Other studies have indicated a benefit of probiotic supplementation in alleviating symptoms of stress. In particular, researchers have looked at stress in students as they prepared for exams, while also evaluating other health indicators such as flu and cold symptoms (1). In healthy people, there is an indication that probiotic supplementation may help to maintain memory function under conditions of acute stress.

Studies of major depressive disorder have been correlated with reduced Lactobacillus and Bifidobacteria and symptom severity has been correlated to changes in Firmicutes, Actinobacteria, and Bacteriodes. Gut microbiota that contain more butyrate producers have been correlated with improved quality of life (1).


A study in healthy women providing probiotic yogurt for four weeks showed an improvement in emotional responses as measured by brain scans (2). A subsequent study by Mohammadi et al. (3) investigated the impacts of probiotic yogurt and probiotic capsules over 6 weeks and found a significant improvement in depression-anxiety-stress scores in subjects taking the specific strains of probiotics contained in the yogurt or capsules. Other studies with probiotics have indicated improvements in depression scores, anxiety, postpartum depression and mood rating in an elderly population (4-7).


Other studies have indicated a benefit of probiotic supplementation in alleviating symptoms of stress. In particular, researchers have looked at stress in students as they prepared for exams, while also evaluating other health indicators such as flu and cold symptoms (1). In healthy people, there is an indication that probiotic supplementation may help to maintain memory function under conditions of acute stress.

References and notes

References and notes

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